Abstract: A medicinal composition having antibiotic, anti-inflammatory, and wound healing activity that inhibits the growth of pathogens by means of a synergistic association of plant extracts of Matricaria recutita, Psidium guajava L., and Plantago major L., and, optionally, Casearia sylvestris SW, for topical application either in the form of biofilm or in the solid dosage form without the use of preservatives is described.